منابع مشابه
Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model
The primary cilium is an organelle protruding from the cell body that senses external stimuli including chemical, mechanical, light, osmotic, fluid flow, and gravitational signals. Skin is always exposed to the external environment and responds to external stimuli. Therefore, it is possible that primary cilia have an important role in skin. Ciliogenesis was reported to be involved in developmen...
متن کاملPrimary cilia
The primary cilium was first so named by Sergei Sorokin in 1968.[1] Since the discovery of primary cilium in 1898 by Zimmerman, three major hypotheses for their function have been put forth. The first is that primary cilia are vestigial organelles inherited from an ancestor whose cells had motile cilia and now are of no purpose in multicellular organisms. The second is that they are involved in...
متن کاملPrimary cilia in bone.
lization. This independence of calcium and PGE 2 has been reported previously and suggests that there are multiple mechanisms by which bone cells sense their mechanical environment. These findings are currently in press in the Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. by oscillatory fluid flow via intracellular calcium mobilization and activation of ...
متن کاملHIF Stabilization Weakens Primary Cilia
Although solitary or sensory cilia are present in most cells of the body and their existence has been known since the sixties, very little is known about their functions. One suspected function is fluid flow sensing- physical bending of cilia produces an influx of Ca++, which can then result in a variety of activated signaling pathways. Defective cilia and ciliary-associated proteins have been ...
متن کاملPericentrin pivotal in primary cilia
Pericentrin pivotal in primary cilia he centrosome protein pericentrin acts as an anchor for primary cilia formation in human cells, according to a report by Jurczyk et al. (page 637). The finding further unites the centrosome and primary cilia, both of which are based around centri-oles, and both of which use pericentrin as an anchor for other proteins. The authors show that pericentrin is loc...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2014
ISSN: 0906-6705
DOI: 10.1111/exd.12426